Alumni-Club

Publications
Willier, S., Butt, E., Richter, G.H.S., Burdach, S., Grunewald, T.G.P., 2011. Defining the role of TRIP6 in cell physiology and cancer. Biol. Cell 103, 573–591. https://doi.org/10.1042/BC20110077

Willier, S., Butt, E., Grunewald, T.G.P., 2013. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. Biol. Cell 105, 317–333. https://doi.org/10.111/boc.201300011

Grunewald, T.G.P.*, Willier, S.*, Janik, D., Unland, R., Reiss, C., Prazeres daa Costa, O., Buch, T., Dirksen, U., Richter, G.H.S., Neff, F., Burdach, S., Butt, E., 2013. The Zyxinrelated protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing’s sarcoma and promotes migration, invasion and cell growth. Biol. Cell 105, 535–547. https://doi.org/10.1111/boc.201300041 *shared first-authorship

Blaeschke, F., Stenger, D., Kaeuferle, T., Willier, S., Lotfi, R., Kaiser, A.D., Assenmacher, M., Döring, M., Feucht, J., Feuchtinger, T., 2018. Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing
Since 02/2021 neonatal intensive care unit rotation
01/2021 post-doc in the Feuchtinger Lab (Kubus research center)
08/2020-12/2020 paternal leave
11/2019-7/2020 post-doc in the Feuchtinger Lab (Kubus research center)
04/2019-10/2019 clinical rotation in pediatrics (sonography, oncology)
10/2016-3/2019 post-doc in the Feuchtinger Lab (Kubus research center)
10/2014-9/2016 intern at the Dr. von Hauner childrens hospital („common trunk“) practice system for the treatment of CD19+ acute lymphoblastic leukemia. Cancer Immunol. Immunother. 67, 1053–1066. https://doi.org/10.1007/s00262-018-2155-7

Willier, S., Cabanillas Stanchi, K.M., von Have, M., Binder, V., Blaeschke, F., Feucht, J., Feuchtinger, T., Döring, M., 2019. Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy – results of a non-interventional observation study. BMC Cancer 19, 1118. https://doi.org/10.1186/s12885-019-6252-6

Kaeuferle, T., Krauss, R., Blaeschke, F., Willier, S., Feuchtinger, T., 2019. Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation. J Hematol Oncol 12, 13. https://doi.org/10.1186/s13045-019-0701-1

Blaeschke, F., Paul, M.C., Schuhmann, M.U., Rabsteyn, A., Schroeder, C., Casadei, N., Matthes, J., Mohr, C., Lotfi, R., Wagner, B., Kaeuferle, T., Feucht, J., Willier, S., Handgretinger, R., Stevanović, S., Lang, P., Feuchtinger, T., 2019. Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy. Cytotherapy. https://doi.org/10.1016/j.jcyt.2019.06.009

Kaeuferle, T., Deisenberger, L., Jablonowski, L., Stief, T.A., Blaeschke, F., Willier, S., Feuchtinger, T., 2020. CRISPR-Cas9-Mediated Glucocorticoid Resistance in Virus-Specific T Cells for Adoptive T Cell Therapy Posttransplantation. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2020.06.002

Blaeschke, F., Willier, S., Stenger, D., Lepenies, M., Horstmann, M.A., Escherich, G., Zimmermann, M., Rojas Ringeling, F., Canzar, S., Kaeuferle, T., Rohlfs, M., Binder, V., Klein, C., Feuchtinger, T., 2020. Leukemia-induced dysfunctional TIM-3+CD4+ bone marrow T cells increase risk of relapse in pediatric B-precursor ALL patients. Leukemia. https://doi.org/10.1038/s41375-020-0793-1

Willier, S., Raedler, J., Blaeschke, F., Stenger, D., Pazos Escudero, M., Jurgeleit, F., Grünewald, T.G.P., Binder, V., Schmid, I., Albert, M.H., Wolf, A., Feuchtinger, T., 2020a. Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells. J Immunother Cancer 8. https://doi.org/10.1136/ jitc-2020-001052 Cabanillas Stanchi, K.M.*, Willier, S.*, Vek, J., Schlegel, P., Queudeville, M., Rieflin, N., Klaus, V., Gansel, M., Rupprecht, J.V., Flaadt, T., Binder, V., Feuchtinger, T., Lang, P., Handgretinger, R., Döring, M., 2020. Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. Drug Des Devel Ther 14, 3915–3927. https://doi.org/10.2147/DDDT.S260887 *shared first-authorship

Stenger, D., Stief, T.A., Käuferle, T., Willier, S., Rataj, F., Schober, K., Vick, B., Lotfi, R., Wagner, B., Grunewald, T., Kobold, S., Busch, D.H., Jeremias, I., Blaeschke, F., Feuchtinger, T.F., n.d. Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR. Blood. https://doi.org/10.1182/ blood.2020005185

Willier, S., Rothämel, P., Hastreiter, M., Wilhelm, J., Stenger, D., Blaeschke, F., Rohlfs, M., Kaeuferle, T., Schmid, I., Albert, M.H., Binder, V., Subklewe, M., Klein, C., Feuchtinger, T., 2020b. CLEC12A and CD33 co-expression as preferential target on pediatric AML for combinatorial immunotherapy. Blood. https://doi.org/10.1182/blood.2020006921

Blaeschke F, Stenger D, Apfelbeck A, et al. Augmenting anti-CD19 and anti-CD22 CAR Tcell function using PD-1-CD28 checkpoint fusion proteins. Blood Cancer J 2021;11(6):108. https://doi.org/10.1038/s41408-021-00499-z

Stief TA, Kaeuferle T, Müller TR, et al. Protective T cell receptor identification for orthotopic reprogramming of immunity in refractory virus infections. Mol Ther [Epub ahead of print]. https://doi.org/10.1016/j.ymthe.2021.05.021