Alumni-Club

Vita Dr. rer. nat. Sanil Bhatia, Preisträger 2018

Thema
„Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response“

Education
Doctoral thesis: Role of nucleolin in regulating HSCs & during leukemia
Subject: Leukemia Biology
University: HHU Duesseldorf
Doctoral Degree: Dr. rer. nat.
Year of graduation: 10/2010 - 2/2015
Grade: Magna cum laude
      
Master thesis: Transcriptional regulation of ESCs differentiation
Subject: Molecular Biology
University: University of Hertfordshire, Hatfield, UK
Degree: MS (research)
Year of graduation: 9/2009 - 10/2010
Grade: A+ (Distinction)
      
Subject: Biotechology (3/2005 – 4/2008)
University: G.N.D.U, Amritsar, India
Degree: BS
Year of graduation: 3/2005 - 4/2008
Grade: A
 

Work experience and Post-Graduate training
8/2018 – Present: Prinicipal investigator, HHU Duesseldorf, Germany
2015 – 2018:  Postdoctoral Fellow, HHU Duesseldorf, Germany
 

Grants & Awards
2018: Erna Brunner Prize Forschungspreis „Stiftung des Fördervereins für krebskranke Kinder Tuebingen“
     
2018: Forschungskommissions (FoKo) grant for a doctorate Position / in (E13 65%), HHU, Duesseldorf
      
2018: Publication selected for the top story at ‘Cancer Stem Cells News’
      
2017: Travel award for attending and presenting research at ASH scientific meeting, Atlanta
      
2016: Duesseldorf Forschungspreis for Kinder- und Jugendmedizin, HHU, Duesseldorf‚ for the best publication‘
 

Selected publications
Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, Borkhardt A, Kurz T, Christianson DW, Hauer J, Hansen FK. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 8. doi: 10.1021/acs.jmedchem.8b01487. PubMed PMID: 30365892.

Mahotka C, Bhatia S, Kollet J, Grinstein E. Nucleolin promotes execution of the hematopoi-etic stem cell gene expression program. Leukemia. 2018 Aug;32(8):1865-1868. doi: 10.1038/s41375-018-0090-4. Epub 2018 Mar 8. PubMed PMID: 29572507.

Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response. Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. PubMed PMID: 29724897.

García-Ramírez I* & Bhatia S*, Rodríguez-Hernández G, González-Herrero I, Walter C, González de Tena-Dávila S, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Domínguez V, Pintado B, Blanco O, Alonso-López D, De Las Rivas J, Martín-Lorenzo A, Jiménez R, García Criado FJ, García Cenador MB, Lossos IS, Vicente-Dueñas C, Borkhardt A, Hauer J, Sánchez-García I. Lmo2 expression defines tumor cell identity during T-cell leukemogenesis. EMBO J. 2018 Jul 13;37(14). pii: e98783. doi: 10.15252/embj.201798783. PubMed PMID: 29880602

Bhatia S, Reister S, Mahotka C, Meisel R, Borkhardt A, Grinstein E. Control of AC133 / CD133 and impact on human hematopoietic progenitor cells through nucleolin. Leukemia. 2015 Nov;29(11):2208-20. doi: 10.1038/leu.2015.146. Epub 2015 Jun 19. PubMed PMID: 26183533.