Alumni-Club

Vita PD Dr. Denis Schewe, Preisträger 2017

Thema
„PGBD5 promotes site-specifi c concogenic mutations in human tumors“

Current Position
Since 12/2016 Principal investigator and Pediatric Oncology Fellow, Department of Pediatric Oncology and Hematology Charité - University Hospital Berlin, Germany


Work Experience and Post-Graduate Training
12/2013-12/2016 Research Fellowship, Pediatric Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

01/2012-12/2013 Residency, Pediatrics, University Children‘s Hospital Essen, Germany

06/2010-06/2011 Internship, Pediatrics, Hôpital Necker, Paris, France


Education
2007-2012 Doctoral Thesis, Neuroscience (Grade: 1.0)
RWTH Aachen, Aachen, Germany

2004-2011 Medical School, M.D. (Grade: 1.83),
University of Düsseldorf, Germany

2004 Abitur (High school, Grade: 1.2)
St. Ursula Gymnasium, Düsseldorf, Germany


Awards and Memberships
2018 Erna Brunner Prize

2017 Berlin Institute of Health (BIH) Paper of the month

2017 American Association for Cancer Research (AACR) Fellow-in-Training Award

2007 Human Brain Mapping Award

2017 German Cancer Consortium (DKTK) Investigator

since 2012 American Association of Cancer Research (AACR) member

since 2017 Advances in Neuroblastoma Research Association (ANRA) member

since 2017 Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH)


Languages (fluent spoken and written)
English, German, French


Selected Presentations
Henssen, A.G. et al., Therapeutic targeting of PGBD5-induced DNA repair dependence in pediatric solid tumors, Oral presentation, AACR Annual Meeting, Washington D.C., USA, 2017

Henssen, A.G. et al., Targeting MYCN-driven transcription by BET-bromodomain inhibition. Oral presentation, AACR Annual Meeting, Philadelphia, USA, 2016

Henssen, A.G. et al., Human tumorigenesis induced by endogenous DNA transposase. Poster presentation, AACR Annual Meeting, Philadelphia, USA, 2015

Henssen, A.G. et al., BET protein inhibitor ,OTX015, has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastoma. Poster presentation, AACR Annual Meeting, San Diego, USA, 2014


Peer-reviewed publications Publications (extract)
Henssen, A.G., Reed, C., Jiang, E., Dorado Garcia, H., von Stebut, J., MacArthur, I.C., Hundsdoerfer, P., Kim, J.H., de Stanchina, E., Kuwahara, Y., Hosoi, H., Ganem, N.J., Dela Cruz, F., Kung, A.L., Schulte, J.H., Petrini, J.H., Kentsis, A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med, 2017 (IF 16.7)

Henssen, A.G., Koche, R. Zhuang J., Jiang E., Reed C., Eisenberg A., Still E., MacArthur I.C., Rodríguez-Fos E., Gonzalez S., Puiggròs M., Blackford A.N., Mason C.E., de Stanchina E., Gönen M., Emde A.K., Shah M., Arora K., Reeves C., Socci N.D., Perlman E., Antonescu C.R., Roberts C.W.M., Steen H., Mullen E., Jackson S.P., Torrents D., Weng Z., Armstrong, S.A. & Kentsis, A., PGBD5 promotes site-specific oncogenic mutations in human tumors, Nat. Genet. 2017 (IF 31.6)

Henssen, A.G., Odersky A., Szymansky A., Seiler M., Althoff K., Beckers A., Speleman F., Schäfers S., De Preter K., Astrahanseff K., Struck J., Schramm A., Eggert A., Bergmann A., Schulte J.H. Targeting tachykinin receptors in neuroblastoma. Oncotarget. 2016 (IF: 5.0)

Henssen, A. G., Jiang E., Zhuang J., Pinello L., Socci N.D., Koche R., Gonen M., Villasante C. M., Armstrong S. A., Bauer D. E., Weng Z., Kentsis A. . Forward genetic screen of human transposase genomic rearrangements. BMC Genomics 2016 (IF 3.8)